Abstract
Summary
The binding characteristics of the hypocholesterolemic agent cholestyramine for flufenamic and mefenamic acids were examined in vitro and in vivo. Both drugs strongly interact in vitro with the resin, and the presence of physiologic concentrations of conjugated bile salt anions competitively inhibits, but does not totally prevent, this interaction. When flufenamic acid or mefenamic acid and the resin were coadministered orally to fasted rats, a 60-70% reduction in both the rate and extent of absorption of these acids was observed. These results suggest that the therapeutic response elicited by these drugs may be seriously affected by concurrent administration of the resin. Also, the resin may prove to be useful in the treatment of acute fenamate intoxication.
Get full access to this article
View all access options for this article.