Abstract
Summary
A histopathologic study of serumtransmitted immune polioencephalomyelitis in C58 mice showed that the inflammatory nature of the CNS lesions in the serumtransmitted disease did not differ significantly from the disease actively induced by inactivated syngeneic malignant lymphocytes. The histopathology was characterized by perivascular lymphocytic infiltrates in the gray matter of the spinal cord and brain stem with accompanying microglial proliferation and neuronal destruction. Demyelination, inclusion body formation, astrocyte proliferation, and cerebral and cerebellar involvement were absent. Evidence was summarized indicating that the active serum component was not an immunoglobulin but probably a processed antigen or a lymphokine. The disease appears to result from an age-dependent autoimmune response to theta or theta-like antigens common to CNS tissues and lymphoid cells.
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