Abstract
Summary
Hamster embryo cells infected with GPHLV showed morphological cellular transformation. Virus strains isolated from leukemic guinea pigs showed somewhat higher transforming capacity than the isolates from “normal” Hartley guinea pigs. Virus specific antigen was detected in the cytoplasm of 7-20% of the transformed hamster cells. Infectious virus could be recovered from the transformed cells by co-cultivation with guinea pig kidney cells. Quantitative analysis showed that in these cell lines 12-47/100,000 transformed hamster cells yielded infectious virus.
The authors are grateful to Dr. R. H. Green for his valuable suggestions during the preparation of this manuscript. The excellent technical assistance of JoEllyn Bradley and Judy Wnek is appreciated.
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