Abstract
Summary
After stimulation in vivo with heat-killed Staphylococcus aureus, rat peritoneal granulocytes and macrophages produced leukocytic endogenous mediator (LEM). When this LEM was injected into normal rats, it lowered plasma iron and zinc concentrations and markedly increased blood neutrophils. Incubation of macrophages. blood leukocytes, or Kupffer cells with S. aureus in tissue culture media and rat plasma in vitro gave low yields of LEM. Further evidence was presented to show that serum taken from rats 4 hr after an ip injection of Diplococcus pneumoniae contained LEM.
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