Abstract
Summary
Pentobarbital-anesthetized rats of both sexes received intravenous infusions of isotonic saline, with or without gelatin and/or salmon calcitonin. Each animal served as its own control. Diuresis, natriuresis and increased GFR followed the addition of gelatin to saline infusions. Similar effects were observed when gelatin plus calcitonin were added to the saline infusion. Calcitonin may have increased sodium excretion, but did not affect urine flow rate or GFR when added to infusions of gelatin. No effect on potassium excretion was seen. Therefore gelatin is diuretic and natriuretic and calcitonin may be natriuretic but not diuretic when infused into the anesthetized rat. The changes in urine flow rate and sodium excretion were not caused by changes in GFR, suggesting altered tubular function as the cause.
This research was supported by National Science Foundation Grant GB 35263, and grants from the Michigan Heart Association and Kidney Foundation of Michigan.
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