Abstract
Summary
Female rat pups injected sc with 1.0 mg testosterone propionate in 0.1 ml sesame oil on day 5 of life were given a single dose of FSH (200 μg) or LH (25 μg) iv or LHRH (3.0 μg) sc at 1:30 pm on day 30, 45, 60, 75, 90, 120, or 150. Normal cyclic rats were given FSH or LH in the same manner on the second day of diestrus at the same days of age. The data indicate that follicles in androgenized rats are ready to respond to exogenous and induced-endogenous gonadotropin, and that the ovarian threshold to gonadotropin decreases with age. However, the androgenized rats require more gonadotropin than their cyclic rat contemporaries receiving exogenous gonadotropin in order to produce the same ovulatory response.
The author thanks Dr. Roy O. Greep for his interest and support during the course of this study.
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