Influence of Castration and Testosterone Propionate on Cardiac Output,Renal Blood Flow,and Blood Volume in Mice 1

Abstract

Summary

The cardiac output and renal blood flow has been determined in mice by the adaptation of the ⁸⁶Rb method of Sapir-stein. Cardiac output also was determined with [¹³¹I] albumin. Castration decreased the cardiac output, renal ⁸⁶Rb uptake and renal blood flow. Testosterone propionate was ineffective after 2 days but within 7 days had restored these values to normal. Extension of the androgen treatment did not produce any further changes. The blood volume of the mice was decreased approximately 10% by castration and restored to normal by testosterone propionate.