Abstract
Summary
Development of hypertension in unanesthetized dogs in response to rabbit anti-canine kidney glomerular antiserum (IgG) was examined over periods of time totalling 7.5–9 mo. The dosage of IgG was such as to cause minimal renal functional alterations, and BUN remained normal. Two of three dogs studied developed hypertension. Plasma renin and aldosterone value were not increased. Tentative mechanisms for the observed hypertension are discussed in the light of possible failure of the kidney medulla to produce and release depressor material.
We are indebted to Chris Amneus and Carol Van Ermen for valuable technical assistance; to Dr. Myron Weinberger, Department of Medicine, for the radioimmune assays of renin and aldosterone, and to Dr. Roger P. Maickel, Department of Pharmacology, Bloomington, for the catecholamine assays.
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