Abstract
Summary
Germfree, specifically mono-associated with bacteria, and conventional CFW mice were evaluated for changes in serum CSF levels following 850 R whole-body X-irradiation. Gram-negative E. coli-monoassociated mice showed elevations of CSF levels similar to that in conventional mice. However, CSF levels in mice mono-associated with S. faecalis remained unchanged, as in germfree mice. In mice with bone marrow transplantations following X-irradiation, serum CSF levels were maintained at the level of untreated mice, which indicates that CSF levels are regulated by functioning bone marrow cells. The data also indicates that the changes in CSF levels that are associated with gram-negative bacteria may be due to the production of endotoxin, which is involved in levels of serum CSF; which, in turn, may play a role in regulating granulopoiesis.
We express our thanks to Dr. Donald Metcalf for his valuable advice in implementation of this project.
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