Abstract
Summary
Oxidative degradation of phospholipid in rat liver microsomes accompanied by degradation of added thyroxine can be effected in at least two different systems. One of these is NADPH-dependent (enzymatic) and the other is Fe3+-ascorbate-dependent (nonenzymatic). Ascorbate can replace the NADPH as the substrate in the enzyme-catalyzed reaction.
In addition, the ferric iron-adenosine diphosphate complex, which serves as a catalyst in the NADPH-dependent lipid peroxidation, can also in the presence of rat liver microsomes catalyze thyroxine degradation without lipid peroxidation.
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