Acute Oral Toxicity of N-2-Fluorenylacetamide (2-FAA) in Several Strains of Mice 1

Abstract

Summary

The oral LD₅₀/7 day of 2-FAA has been determined in both sexes of the following strains of mice: CD-1, C57BL/6Cr, C57BL/6j, and BALB/cj. Symptoms of toxicity included: lethargy, sedation, loss of righting reflex, circling, orange-red urine, bladder concretions and paralysis with all limbs rigidly extended. Deaths peaked between 48 and 72 hr. Particle size was shown to affect the LD₅₀/7 day in CD-1 mice. His-topathological examination of the tissues indicated they were essentially normal.

The authors thank S. Poiley for the C57BL/6Cr mice used in this study, and Drs. W. Jacques and C. Frith for the histopathological evaluations.