Cardiovascular Pharmacology of Prostaglandin B 1 and B 2 in the Intact Dog 1

Abstract

Summary

The effects of intravenous PGB₁ and PGB₂ on systemic pressure, HLPP, HP PP, PAP and LVP were evaluated in intact anesthetized dogs. Both PGB₁ or PGB₂ decreased SAP, LVP and HR but did not affect either RAP or LVEDP. These PGB-induced decreases in systemic pressure probably reflected the decreased LVP as well as vasodilatation in the renal bed. Since PGB₁ and PGB₂ both increased PAP without increased LVEDP, the data suggest that these prostaglandins increased the resistance across the lungs. Furthermore, PGB₂ was a potent constrictor of the perfused canine hindpaw when administered intra-arterially into the paw or intravenously. The data are compatible with the conclusion that PGB₁ and PGB₂ possess vasodilator and vasoconstrictor activity on the canine cardiovascular system. PGB₂ is a more potent prostaglandin than PGB₁.

The authors express their appreciation to Miss Marilyn F. Mosle for her excellent technical assistance. The generous gift of PGB₁ and PGB₂ from Drs. J. R. Weeks and J. E. Pike of the Upjohn Co., Kalamazoo, MI, is gratefully acknowledged.