Abstract
Summary
The plasmas of 14 nonhuman mammalian species corrected the specific clotting defect in human hemophilic plasma. The antihemophilic factor (AHF, Factor VIII) activity in all these plasmas was inhibited by human circulating anticoagulants directed against AHF and, except for rabbit AHF, by rabbit antiserum to purified normal human AHF, but human AHF was more readily inhibited than animal plasmas by both these agents. Porcine AHF was more resistant than bovine AHF to inhibition by all of 6 human circulating anticoagulants.
In immuno-precipitation studies using rabbit antiserum, primate plasmas gave reactions of identity with human plasma, while non-primate mammalian plasmas gave reactions of partial identity. Plasma from a reptile and from two avian species contained no detectable antigen or clot-promoting properties related to human AHF.
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