Abstract
Summary
Potassium canrenoate in low concentrations caused a negative inotropic effect, increased heart rate and increased coronary flow in isolated guinea pig hearts. It failed to modify ouabain-induced arrhythmias in Langendorff preparations except at very high concentrations where the effect could be due to K+ ion. Potassium canrenoate did not inhibit (Na+ + K+)-ATPase nor did it modify the ouabain-enzyme interaction.
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