Abstract
Summary
Gastrin concentrations in the blood draining the gastric antrum were measured by radioimmunoassay during changes in the antral pH. Neutralization of the antrum (raising the basal ambient pH of 3.5-5 to 7 or 8) resulted in a significant increase of antral venous gastrin concentration. Acidification of the antrum significantly lowered, but did not abolish, the basal release of gastrin.
These studies demonstrated, by direct measurement of gastrin, the presence of a very sensitive feedback mechanism between antral pH and gastrin release, and that gastrin may be released by simply raising the basal antral pH to 7.
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