Abstract
Summary
Calcium stimulated RNA synthesis in rat heart ventricular slices. Concentrations of calcium ranging from 0.01 to 4.0 mM augmented the incorporation of [3H]-uridine into RNA, in 2 phases, one occurring at low concentrations of calcium (0.01-0.1 mM) and the other around the physiological concentration (2.5 mM). The rate of incorporation is linear for 60-90 min at all concentrations but plateaued after 120 min at the high concentions. Actinomycin D completely inhibited the calcium effect. Calcium appeared to be required for maximal RNA biosynthesis. This increased rate of synthesis of RNA may be a factor involved in the increased stimulation of protein anabolism by calcium.
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