Abstract
Summary
The addition of palmitate, octanoate, or glucose to hearts perfused with Krebs-Henseleit bicarbonate medium containing 5.56 mM glucose resulted in little, if any, change in developed tension. The same substrates, however, produced marked increases in developed tension when administered to hearts made hypodynamic with substrate-free medium. The addition of delta-4-pentenoic acid to the substrate-free medium prevented the positive inotropic actions of palmitate and glucose and partially reduced that of octanoate. These data suggest that these three substrates exert their actions on the force of contraction as a consequence of their metabolism.
Palmitate produced an increase in coronary resistance in the perfused rat heart. This effect is apparently a function of the amount of palmitate which is not bound to albumin.
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