Abstract
Summary
Administration of methylandrostenediol, methyltestosterone and testosterone to hypophysectomized rats failed to produce the hypertensive vascular disease usually seen in normal animals receiving the same androgens. It is, therefore, evident that the pituitary, in addition to the adrenals, plays an essential role in the pathogenesis of androgen-induced hypertension and it is very likely that the constant stimulation of the adrenal gland by ACTH is essential to the development of such hypertensive disease.
This work was supported by Research Grant HE 06975 from the National Heart and Lung Institute and by Training Grant GM 01500 from the National Institutes for General Medical Sciences, Bethesda, MD. The authors thank Mr. L. Joseph, Mrs. D. Ide, Mrs. G. Joseph, and Mrs. B. Cole for technical assistance.
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