Abstract
Summary
Kininogen and erythropoietin are both alpha glycoproteins. Erythropoietin activity increases in the plasma of rats treated with cobalt, reaching a maximum activity 12 hr after cobalt treatment. The kininogen level of the plasma rises significantly after cobalt treatment, reaching maximum 4 hr after cobalt treatment. It appears that an increase in the kininogen level of the plasma precedes the increase in the erythropoietin activity of the plasma. This could suggest that the alpha globulins, of which the kininogen is a part, may be serving as a substrate for the production of erythropoietin.
The data could also suggest that tissue anoxia caused by cobalt treatment, or cobalt itself, may alter the rate of synthesis of kininogen or the rate of utilization of circulating kininogen.
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