Abstract
Summary
Protein-load proteinuria was induced in rats by either intraarterial infusions lasting 1 1/2 hr or by 4 daily, intraperitoneal injections. Control rats were given medium molecular-weight dextran to assess the effect of colloid osmotic load. Glomerular polyanion was reduced histochemically in animals with proteinuria. Reduction of glomerular polyanion and epithelial foot process fusion both may be secondary to proteinuria. Eidence that the negatively charged sialoprotein may be responsible for maintenance of epithelial foot processes is discussed.
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