Abstract
Summary
Immature rats were fed graded levels of sodium cyclamate in conjunction with either a highly purified diet or a natural food-stock ration. On the stock ration, sodium cyclamate when fed at levels of 2.5%, 5% or 10% of the diet had little, if any, adverse effect on weight increment and none on gross appearance. When fed at comparable levels in the purified diet, however, sodium cyclamate caused a significant retardation in growth which was proportional to the level fed, an unthrifty appearance of the fur, varying degrees of alopecia, extensive diarrhea; and at the 10% level of feeding, death. Similar findings were observed in both male and female rats. The deleterious effects of sodium cyclamate when incorporated in the purified diet were manifest after only 3 days of feeding. The protective factor or factors in the stock ration was distinct from any of the known nutrients.
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