Abstract
Summary
African green-monkey kidney cell clones partially resistant to SV40 have been isolated in viral-specific anti-serum from chronically infected cultures. These clones were virus-free and produced no T antigen. One clone was found to be partially resistant to infection with SV40 virions but susceptible to infection by SV40 DNA. Chronically infected cultures were cured of infection by treatment with SV40 anti-serum while maintaining their partial resistance to SV40.
This investigation was supported by Public Health Service Research grant AI-01992, a Damon Runyon postdoctoral fellowship (DRF-466), and by the Denver M. Eckert Special Grant for Cancer Research from the American Cancer Society (Grant E-612).
The authors gratefully acknowledge the encouragement and advice of Dr. William S. Reznikoff.
Get full access to this article
View all access options for this article.