Abstract
Summary
Glutamic-oxalacetic and lactic dehydrogenase activity associated with human beta-lipoprotein can be increased by exposure to sonic radiation. Maximum activity is reached earliest in solutions having a low salt concentration and an acidic pH. The increase in activity occurs concomitantly with an increase in hydrogen ion concentration and specific viscosity. Disruption of the lipoprotein molecule is evidenced by increased viscosity, increased turbidity, and decreased immunologic reactivity toward a specific antiserum. Enzymic activity found in beta-lipoprotein isolated by using two radically different techniques gave equivalent results when exposed to radiation. This strongly mitigates against the possibility of an isolation artifact.
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