Influence of Endotoxin Tolerance on Detoxification of Salmonella enteritidis Endotoxin by Mouse Liver and Spleen 1

Abstract

Summary

The influence of tolerance, developed by the daily intraperitoneal administration of sublethal doses of Salmonella enteritidis endotoxin, on the endotoxin detoxifying capacity of the liver and spleen was evaluated. Liver and spleen homogenates from endotoxin-tolerant mice possessed greater endotoxin detoxifying ability than liver and spleen homogenates from saline-treated mice.

These findings further accent the importance of the liver and spleen macrophage cells in endotoxemia and indicate that endotoxin tolerance is associated with the enhanced capacity of the reticuloendothelial cells to detoxify endotoxin.