Abstract
Summary
The individual serum cholesterol of 21 adult male New Zealand white rabbits were maintained constant at certain fixed levels ranging from 31 to 2486 mg/100 ml among the group for 60 days by frequent adjustment of their dietary cholesterol intake. The cholesterol contents of 15 different tissues of all rabbits were determined at the end of the 60 day experiment. Brain and muscle did not show any significant change in their cholesterol contents. The cholesterol contents of most tissues including liver, adrenal, testis, kidney, colon, small intestine, heart, pancreas and adipose tissue increased linearly in proportion to serum cholesterol levels, whereas that of skin, aorta, spleen and lung increased exponentially with the elevation of serum cholesterol levels. The study thus provided evidence of variations in the susceptibility of different tissues to deposition of excessive cholesterol.
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