Abstract
Summary
α-Globulin fraction prepared from normal human plasma suppressed first as well as second set skin allograft reactions in rats.
Spleen cells taken from mice, immunized by transplantation of skin allografts, and incubated with the α-globulin fraction failed to transfer transplantation immunity to isologous recipients.
No evidence was obtained for cytotoxicity of α-globulin. Since human serum albumin failed to suppress immune response the mode of action of α-globulin was not considered to be due to antigenic competition.
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