Abstract
Summary
A collagen wound dressing derived from edible bovine corium has been investigated for application as a primary dressing for normal-excised and burn-excised wound in rodents and pigs.
Utilizing the rate of wound closure as an end point, the microcrystalline collagen wound pad was superior to a gauze dressing. A significant enhanced wound closure rate was demonstrated by the microcrystalline collagen wound dressing earlier in wound healing (Days 4-6) with a resultant earlier total closure of the wound as evaluated against control wounds dressed with gauze.
The microcrystalline collagen wound dressing demonstrated no untoward reaction indicative of inflammation or infection, but does appear to assist in the normal wound healing process. The above results merit further investigation of the material in other wound healing models.
Acknowledgements: Appreciation is expressed to Collagen Research Associates, Princeton, New Jersey for their technology; also to the Product Development Dept. (Dr. G. Hecht) for microcrystalline collagen dressings and to Dr. O. A. Battista (Avicon, Ft. Worth, Tex.), Dr. Milos Chvapil (U. of Arizona, Tucson, Arizona) and Dr. C. A. Baxter (U. of Texas-Dallas Southwest Medical School, Dallas, Tex.).
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