Abstract
Summary
In two strains of rats with opposite genetic propensities to hypertension, the effect of renal transplants on the chronic blood pressure response has been studied. 113 rats survived an average of 4 months (range 1-14) after this procedure. Among animals maintained on a low NaCl diet, blood pressure, as compared with appropriate controls, was not significantly affected when the recipient animal and its renal homograft came from the same strain; however, animals from the hypertension-resistant strain with a renal homograft from the hypertension-prone strain had higher pressures whereas hypertension-prone rats with a homograft from the hypertension-resistant strain had lower pressures than their respective controls. Thus, the phenotypic response—blood pressure—was more influenced by the genotype of the renal homograft than by the genotype of the recipient.
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