Abstract
Summary
Injection of leucogenenol into splenectomized rats together with sheep erythrocytes, results in the formation of normal titers of 19S hemolysin. Injection of leucogenenol, together with sheep erythrocytes into normal rats does not result in increased hemolysin titers. The distribution and concentration of 19S and 7S proteins in the serum is not affected by leucogenenol. It is suggested that leucogenenol acts by increasing the rate of transformation of immunoincom-petent cells, possibly a type of lymphocyte, into antigen-reactive lymphocytes.
We thank Dr. E. J. Leonard, NCI, NIH, for the rabbit antirat serum antiserum.
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