Abstract
Conclusion
Cell replication is perturbed in the rat ileal crypt cells and spleen lymphocytes following 5 days of HN2, MTX or HC. At the dosage levels employed HN2 produces leukopenia, MTX causes anemia and HC does not affect the blood count. Histologically there is a loss of spleen lymphocytes following the administration of each of the drugs. Methotrexate also causes flattening of the intestinal villi without evidence of necrosis.
The authors thank Tatiana Miheyev, Dr. Bruce Pachter and Dr. Robert Sklarew for their technical assistance.
Get full access to this article
View all access options for this article.