Abstract
Summary
Polyriboinosinic·polyribocytidylic acid [poly(I)·poly(C)] complexed with poly-D-lysine was studied as a prophylactic and therapeutic material in mice inoculated with herpes simplex virus (HSV). With the treatment as described, a higher proportion of mice treated with poly (I)·Poly (C) [poly-D-lysine] survived than when treatment consisted of poly (I)·poly (C) alone, or phosphate buffered saline (PBS) alone, following subcutaneous (sc) inoculation with HSV. This enhanced protection was still detectable if treatment was begun as late as 4 days following sc inoculation of HSV, at which time an occasional mouse was showing signs of early central nervous system illness. The treatment regimen did not appear to adversely alter the immunological responsiveness of sc infected animals as judged by subsequent ic reehallenge with HSV. No mortality was observed as a result of repeated injections of 100 μg of poly (I)·poly (C) complexed with poly-D-lysine.
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