Types of anaphylactic reaction

Abstract

Study of isolated anaphylactic lungs by perfusion methods 1 shows that there are three types of pulmonary anaphylactic reaction:

(a) Bronchial Anaphylaxis, or the spasmodic contraction of the bronchial musculature, unassociated with recognizable changes in the pulmonary blood vessels. This type of reaction is illustrated by the lungs of actively sensitized and actively immunized guinea pigs, and by the lungs of guinea pigs passively sensitized with homologous serum.

(b) Vascular Anaphyalxis, or the spasmodic contraction of the pulmonary blood vessels, usually accompanied with edema. The vascular reation is usually followed by a mild bronchial reaction. This type of reaction is illustrated by the lungs of guinea pigs passively sensitized with heterologous serum, and by the reaction of normal lungs to certain protein split-products and incubated blood mixtures.

(c) Pseudo-Anaphylaxis, or the plugging of the pulmonary blood vessels with thrombi and agglutinated corpuscle masses.