(Na + + K + )-ATPase Activity in the Liver with Hemorrhagic Shock 1

Abstract

Summary

(Na⁺ + K⁺)-ATPase activity was measured in the liver of rats subjected to an early stage of hemorrhagic shock (25% of shed blood taken back spontaneously) and a late stage (50-70% of shed blood taken back). In unbled control animals the activity was 10.6 ± 1.04 (mean ± SEM) nmoles H⁺/(mg protein X min). An approximately twofold increase in activity in early shock and a threefold increase in late shock was found. When animals were treated by return of the shed blood plus 5-6 ml of Ringer's lactate solution in the early and late stages of shock and allowed 1 hr for recovery, the (Na⁺ + K⁺)-ATPase activity decreased to near control levels. These results also indicate that the increased liver (Na⁺ + K⁺)-ATPase activity in shock is reversible with treatment.