Abstract
Summary
Infection of mice with BCG failed to enhance sensitivity to poly rI:rC, as assayed by the amount of polymer required for interferon induction or for lethal toxicity. The amount of interferon induced in normal mice reached a plateau at a poly rI:rC dose of 200 μg per mouse. In contrast, the amount of interferon elaborated by BCG-infected mice following poly rI:rC doses of ≥200 μg per mouse was greater than that of normal mice, and increased with increasing amounts of inducer. Complete hyporeactivity to interferon induction by endotoxin was observed in normal mice pretreated with poly rI:rC, even when the dose of poly rI:rC elicited only a minimal interferon response, whereas a poly rI:rC dose-related hyporeactivity was observed in BCG-infected mice.
The research for this paper was supported by National Institute of Health Grants 5TI AI0128-12 and AI07257-06.
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