Abstract
Summary
The phagocytic clearance of both an inert and metabolizable foreign colloid results in a decrease in hepatic sinusoidal blood flow in both the isolated perfused rat liver and intact animal. While the vascular response was not colloid specific, it was dependent on both the dose injected and the precolloid injection level of stable blood flow. In this regard, the response was directly related to the dose injected and only apparent when the stable flow was within the physiologic range. The temporal relationship between the vascular response and the rate of colloid clearance indicates that the response is a postphagocytic event and dependent on the prior Kupffer cell uptake of the particles. It is suggested that the colloid–induced depression in hepatic blood flow may be a factor mediating the decreased resistance to shock induced by intravenous colloid administration.
The authors acknowledge the fine technical assistance of Mrs. Virginia Stiffel.
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