Abstract
Summary
Oxisuran, 2-[(methylsulfinyl)a-cetyl] pyridine, has been shown to suppress allograft rejection in the rodent without causing concomitant suppression of the hemolytic antibody response to sheep erythrocytes. This simple synthetic compound thus differs from presently defined “immunosup-pressants,” such as 6-mercaptopurine with which it has been directly compared, which from their modes of action fail to discriminate between humoral and cell-mediated immune responses.
The authors are grateful to Dr. Donald L. Ballantyne, Jr., for making available the data in Table II from his collaborative studies on oxisuran.
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