Abstract
Summary
When normal mice were inoculated either intravenously or subcutaneously with cells from tumors (C3H or MC) originating in isogenic hosts or with isologous kidney cells, a profound depression of peripheral blood lymphocytes occurred approximately 2 days later. A similar reduction occurred in mice injected with tumor cells when they had had prior exposure to kidney cells or to cells from a different tumor, i.e., MC tumor cells prior to C3H tumor cell inoculation. No lymphocytopenia was observed, however, if tumor cells were introduced into animals possessing concomitant or sinecomitant tumor immunity, or when kidney cells were injected into mice which had previously been inoculated with syngenic kidney cells. Recipients of ALS prior to and during the presence of immunizing tumors displayed no lymphocytopenia when injected with tumor cell suspensions subsequent to a return of peripheral lymphocytes to normal levels after cessation of ALS.
The technical assistance of Francine Jencka and Christine Rudock is acknowledged with gratitude.
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