Abstract
Summary
DL-a-Methyl aspartic acid and DL-threo-β-methyl aspartic acid have been shown to inhibit, in vitro, both urea synthesis and the conversion of L-citrulline-6-14C to 14C-urea. In the presence of glutamine as nitrogenous substrate, the conversion of citrulline to urea is inhibited while urea synthesis is not inhibited by these methyl aspartates. No inhibition of urea biosynthesis or of conversion of L-citrulline-6-14C to 14C-urea could be demonstrated in the isolated perfused rat liver using these inhibitors.
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