Inhibition of Experimental Amyloidosis in Alloxan Diabetic Mice

Abstract

Summary

A group of 40 mice was rendered diabetic by iv alloxan and then given amyloidogenic treatment. Of the 22 surviving animals, two, in which the diabetes was transitory, developed heavy splenic amyloidosis. Among the 20 mice with sustained diabetes, two developed minimal deposits; whereas in 18, no amyloid deposits were detected. In 30 of 31 animals given only amyloidogenic treatment and in all 30 animals given amyloidogenic treatment and ip alloxan (which did not produce diabetes), heavy splenic amyloidosis developed. The findings indicate that the diabetic state in animals inhibits amyloid deposition.