Abstract
Summary
A purified preparation of type E botulinal toxin possessed serological properties distinct from those of crude preparations. In vitro studies suggested that the specific toxicity of a toxin is not necessarily a true reflection of its relative concentration, and that some type E botulinal toxin molecules exist in a nontoxic or less toxic form than others. Although specific toxicities may be misleading in predicting the relative in vitro behavior of E toxins, it would be expected that purified Sakaguchi toxin would be a better inhibitor in HI than partially purified toxins on a weight basis with purified Sakaguchi SRBC antigen. The purified Sakaguchi toxin appears to be suitable for in vitro investigations and immunoassays.
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