Abstract
Summary
An inhibitor of Herpesvirus hominis is present in extracts of a lymphoid cell line derived from a Burkitt's lymphoma. The inhibitor is demonstrable when monolayer cultures of rat and human cells are treated with the extracts, and although it is active against the herpesvirus in both plaque inhibition and 24-hr growth inhibition experiments, it does not significantly inhibit vesicular stomatitis virus in similar experiments. The inhibitor does not appear to be interferon or an interferon inducer, and the possibility that it is involved in the maintenance of the EB viral genome in an unexpressed or partially expressed form in Burkitt's lymphoma cells is considered.
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