The Metabolism of Estradiol-17β-4- 14 C in the Newborn Rhesus Monkey

Abstract

Summary

Estradiol-17β-4-¹⁴C was rapidly and extensively metabolized by the newborn rhesus monkey. Estrone was the major metabolite identified in both urine and bile, accounting for more than 50% of the recovered radioactivity. The newborn monkey has the capacity, although limited, to 16-oxygenate estrogens. Estriol, 16α-hydroxyestrone, and 16-ketoestradiol-17β were identified; but these comprised only a small portion of the metabolites.