Abstract
Summary
Pretreatment with spironolactone (SPL) or aldadiene enhanced the activity of drug-metabolizing enzymes in mouse liver microsomes. Elevations in components of the microsomal electron transport system and other parameters indicative of enzyme induction were also noted. The nature of the induction by these drugs did not differ qualitatively nor was sex-dependent difference observed. Kinetic studies suggest that the microsomal induction by SPL may be mediated by an increase in the amount of enzyme (V max) rather than by an alteration in the apparent affinity (K m) of the enzyme.
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