Abstract
Summary
Oxytetracycline, α-6-deoxyoxytetracycline, nitrofurantoin, and nalidixic acid were studied in two experimental Escherichia coli models of urinary tract infection in rats, i.e., descending pyelonephritis induced by intravenous injection of the organism after temporary ureter occlusion and ascending pyelonephritis induced by administration of the organism into the bladder followed by manually produced reflux.
Oxytetracycline and α-6-deoxyoxytetracycline, agents which appear in active form in body fluids and tissues, had equal activity in both infection models. Although nitrofurantoin appears in active form only in the urine, equal activity was demonstrated in both infection models. Nalidixic acid, an agent primarily active in the urine, was markedly more active in the ascending than in the descending urinary infection model. A more critical and complete appraisal of chemotherapeutants for use in urinary tract disease would be gained by evaluation in 2 different experimental urinary tract models rather than in a single infection model.
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