Abstract
Summary
In a continuing evaluation of adenovirus sensitivity to interferons the limited but measurable sensitivities of Ad. Types 1, 3, 4, 5, 8, 11, and 18 to human tissue culture interferon were demonstrated in plaque-reduction assays using human embryo kidney cell cultures. Generally similar patterns of interferon-mediated interference were observed for each virus type and for several strains within a single serotype. Similar findings have been reported previously for Ad. Types 2, 7, and 12 (6). The relatively limited sensitivity of adenoviruses to interferons seems to set them apart from many other animal viruses and reinforces a number of recent reports of intrinsic differences in sensitivity to interferon among different viruses.
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