Abstract
Summary
Increased urine volume and increased water intake were shown in genetically obese rats. The increased urine volume persisted despite controlled solute intake and pitressin treatment. Maximum urine concentrating ability and urine proteinuria were similar in lean, genetically obese, and lesioned obese rats. No histological lesions could be identified. The results were discussed in the light of a possible hypothalamic defect in genetically obese rats.
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