Abstract
Summary
Cell fusion between mouse mammary tumor cells and normal mouse cells not only enhanced the production of MTV, as demonstrated by immunofluorescence and electron microscopy, but also appeared to induce infection of normal nonfused cells. In cultures of mouse tumor cells fused with normal rat mammary cells, a definite species specificity of the mouse MTV has been shown, since this virus seemed to replicate exclusively in the mouse tumor cells. In both cases, cell fusion appeared to lower the compatibility barrier of rat recipients to mouse cell transplants but a subsequent infection of the host by MTV could not be demonstrated.
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