Abstract
Summary
Blood pressure was measured in anesthetized dogs during acute selective sodium chloride depletion without water depletion; total osmotic pressure of extracellular fluid was held constant thereby preventing osmotic shift of water into cells. The blood pressure changes seen were not different from those in a control series where sodium concentration remained constant. These studies fail to show that acute sodium chloride depletion per se affects blood pressure. Apparently the blood pressure changes seen with acute manipulation of the total body sodium chloride content are produced indirectly via associated changes in extracellular osmolality.
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