Abstract
Summary
The formation of the nucleotide intermediates adenosine-phosphosulfate (APS) and phosphoadenosine-phosphosulfate (PAPS), and the uptake of radioactive sulfate into chondroitin sulfate was examined using hepatic enzyme preparations from normal and pancreatectomized female rats. It was found that the uptake of 35S into PAPS and chondroitin sulfate is inhibited at high concentrations of enzyme from diabetic female rats, while PAP35S formation is stimulated at lower concentrations of diabetic enzyme. Chondroitin sulfate-35S formation is enhanced in female animals, probably due to greater sulfotransferase activity in the female than in the male.
Get full access to this article
View all access options for this article.