Abstract
Summary
1. A method, employing a continuous avoidance-type behavioral performance schedule in adult male rats, to measure the effects of test agents on ethanol-induced changes in animal performance is described. 2. The test measures discriminatory, drug-ethanol interactions on avoidance behavior, but the number of shocks not terminated was, overall, the most useful parameter to quantify the influence of a test agent on performance in ethanol-treated rats. This effect was calculated as a percentage value and termed “rideouts.” 3. Of the test agents examined in this model those involved in metabolism were the most active inhibitors (e.g., DL-threonine, D-fructose, sodium pyruvate, L-methionine, and DL-glutamine).
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